Characterizing anterior cingulate activation in chronic schizophrenia: a group and single‐subject fMRI study

Abstract

Objective:  Functional abnormalities of the dorsal anterior cingulate (dAC) region have been emphasized in schizophrenia, particularly in relation to cognitive deficits. In this study, we sought to further evaluate the notion of dAC hypofunction in chronic schizophrenia patients using a cognitive task specifically designed to activate this region, enabling both group and single‐subject level analyses.Method:  Twelve male schizophrenia patients and 14 male healthy subjects were studied with functional magnetic resonance imaging (fMRI) and the multi‐source interference task (MSIT). Patients and healthy subjects were matched for age, gender, education, task performance and gross surface morphol..